| Ken Inoki, Tianqing Zhu, and Kun-Liang Guan. |
| tsc2 Mediates Cellular Energy Response to Control Cell Growth and Survival. |
| Cell. 2003;115:577-590.
PMID: 14651849
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| tsc2(tuberin) 偼嵶朎撪偺僄僱儖僊乕傪姶抦偟偰丄嵶朎偺惉挿丄嵶朎巰傪惂屼偡傞 |
亂梫巪亃
寢愡惢峝壔徢(Tuberous Sclerosis Complex; tsc)偼丄敪徢棪栺1/6000偺斾妑揑崅昿搙側忢愼怓懱桪惃堚揱偵傛傝惗偢傞擄昦偺堦偮偱丄慡恎惈懡宯摑幘姵乮懡憻婍偵媦傇椙惈庮釃; hamartoma乯傪掓偡傞丅tsc偼俀偮偺堎側傞尨場堚揱巕偺撈棫偟偨曄堎偵傛傝惗偠丄偦傟傜偺堚揱巕嶻暔偼偦傟偧傟tsc1(hamartin)丄 tsc2(Tuberin)偲偟偰抦傜傟偰偄傞丅tsc偺堚揱巕堎忢偼tsc侾偵20亾丄tsc俀偵80亾擣傔傜傟丄偙偺俀幰偺曄堎偵椪彴徢忬偺嵎傪擣傔側偄丅tsc侾偲tsc俀偼嵶朎撪偱婡擻揑暋崌懱偲偟偰懚嵼偟丄屳偄偵偦偺埨掕惈傪堐帩偟偰偄傞丅偟偐偟側偑傜丄偦傟傜偺抈敀偺庡梫側婡擻偼嵟嬤傑偱柧傜偐偵偝傟偰偄側偐偭偨丅
偙偺悢擭偺堚揱妛揑丄惗壔妛揑尋媶偵傛傝丄tsc暋崌懱偼僀儞僗儕儞傪偼偠傔偲偡傞惉挿場巕偺摥偒傪梷惂偟偰偄傞抈敀幙偱偁傞偙偲偑柧傜偐偵偝傟偨丅偦偺暘巕惗暔妛揑婡彉偲偟偰丄tsc暋崌懱偼丄惉挿場巕傗塰梴乮傾儈僲巁丄摐乯偵傛傝妶惈壔偝傟傞抈敀崌惉偵晄壜寚側tor (target of rapamycin)抈敀偺妶惈傪娫愙揑偵梷惂偟丄敪娻偵怺偔娭梌偡傞抈敀崌惉傪梷惂偡傞丅傑偨惉挿場巕偵傛傝妶惈壔偝傟傞protein kinase B (Akt)偼丄捈愙tsc俀傪儕儞巁壔偡傞偙偲偵傛傝tsc暋崌懱偺婡擻傪尭庛偟偰偄傞偙偲偑柧偐偵偝傟偨丅偮傑傝僀儞僗儕儞摍偺惉挿場巕偼丄Akt傪妶惈壔偡傞偙偲偱tsc暋崌懱偺婡擻傪尭庛偝偣丄tor偵傛傞抈敀崌惉傪妶惈壔偟偰偄傞偲峫偊傜傟傞丅
崱夞丄変乆偼Akt偺嶌梡偵憡斀偟丄嵶朎撪僄僱儖僊乕偺掅壓乮amp/atp ratio偺憹壛)傪姶抦偟偰妶惈壔偝傟傞amp-activated protein kinase(ampk)偑tsc俀傪捈愙儕儞巁壔偟tsc暋崌懱傪妶惈壔偡傞偙偲傪尒偄弌偟偨丅偙傟傜偺敪尒偼丄嵶朎撪atp偺掅壓偵敽偆抈敀崌惉梷惂偲偄偆崻杮揑偼嵶朎墳摎傪棟夝偡傞偆偊偱廳梫偱偁傞偽偐傝偱側偔丄嵶朎奜塰梴乮摐乯偲嵶朎惉挿偺娭傢傝偵tsc暋崌懱偑怺偔娭梌偟偰偄傞偙偲傪帵嵈偡傞丅
挅栘寬愭惗偼杮妛12婜惗偱丄巓枀峑偱偁傞儈僔僈儞戝妛偱僼僃儘乕偲偟偰妶桇拞偱偡 |
