| Atsushi Kamiya, Ken-ichiro Kubo, Toshifumi Tomoda, Manabu Takaki, Richard Youn, Yuji Ozeki, Naoya Sawamura, Una Park, Chikako Kudo, Masako Okawa, Christopher A. Ross, Mary E. Hatten, Kazunori Nakajima, Akira Sawa |
| A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. |
| Nat Cell Biol.2005 Dec;7(12):1167-78. Epub 2005 Nov 20.
PMID: 16299498 |
| 暯惉17擭搙帬夑堛壢戝妛攷巑榑暥妛挿徿庴徿榑暥 |
|
| DISC1偵偍偗傞摑崌幐挷徢娭楢堚揱巕曄堎偵傛傞戝擼旂幙敪払忈奞 |
亂梫巪亃
摑崌幐挷徢偼條乆側堚揱揑梫場丄娐嫬梫場偑棈傒崌偭偨暋嶨堚揱幘姵偲峫偊傜傟偰偄傑偡偑丄 偄傑偩偦偺尨場偼夝柧偝傟偰偄傑偣傫丅
DISC1 (Disrupted-In-Schizophrenia1)偼丄僗僐僢僩儔儞僪偺偁傞惛恄幘姵懡敪壠宯偱摑崌幐挷 徢偺尨場岓曗堚揱巕偺傂偲偮偲偟偰摨掕偝傟偨堚揱巕偱偡偑丄偙偺枹抦偺堚揱巕偺婡擻傪挷傋傞 偙偲偱丄摑崌幐挷徢偺敪徢婡彉傗昦懺儊僇僯僘儉傪柧傜偐偵偡傞庤偑偐傝傪摼傜傟傞偺偱偼側偄 偐偲変乆偼峫偊傑偟偨丅偙偺壠宯偱偼丄摑崌幐挷徢傪偼偠傔偲偡傞庡側惛恄幘姵偵滊姵偟偨恖乆 偼丄愼怓懱嬒峵揮嵗偵傛傝丄DISC1僞儞僷僋幙偺晹暘揑側寚懝偑惗偠偰偄傞(曄堎宆DISC1)偙偲偑 梊應偝傟傑偟偨丅偙傟傑偱偺変乆偺尋媶偵傛偭偰丄DISC1偑偙偺寚懝椞堟偵偍偄偰戝擼旂幙偺敪払 偵廳梫側栶妱傪帩偮偄偔偮偐偺廳梫側僞儞僷僋幙(NUDEL側偳)偲寢崌偡傞偙偲丄傑偨恄宱條嵶朎 (PC12)偺撍婲怢挿偵娭梌偡傞偙偲偑柧傜偐偵側偭偰偄傑偡(Ozeki et al PNAS 2003)丅
崱夞変乆偼丄偝傜偵DISC1偺婡擻夝愅傪恑傔偨寢壥丄埲壓偺偙偲傪柧傜偐偵偟傑偟偨丅DISC1偼 旝彫娗嵶朎崪奿娭楢dynein motor
complex傪宍惉偡傞僞儞僷僋幙偺傂偲偮偱偁傝丄攟梴嵶朎丄 媦傃梀憱拞偺恄宱嵶朎偺拞怱懱偵嬊嵼偟丄旝彫娗嵶朎崪奿偺宍惉偵娭梌偟偰偄傑偡丅 傑偨丄曄堎宆DISC1偼丄NUDEL偲偺寢崌偑幐傢傟偰偄傞偵傕偐偐傢傜偢丄惓忢側DISC1偲寢崌偡傞 偙偲偱丄偦偺嬊嵼傪曄壔偝偣丄偝傜偵偼dynein, NUDEL偲偄偭偨拞怱懱娭楢僞儞僷僋幙孮偺嬊嵼 傪傕忈奞偡傞偙偲偱丄旝彫娗嵶朎崪奿偺宍惉傪忈奞偡傞僪儈僫儞僩僱僈僥傿僽側婡擻傪帩偮壜擻 惈偑偁傞偙偲傪帵偟傑偟偨丅傑偨丄儅僂僗偺戝擼旂幙敪払抜奒偵偍偄偰DISC1偺僞儞僷僋幙敪尰傪 梷惂偡傞偙偲偱丄惓忢側曻幩忬恄宱嵶朎堏摦(radial neuronal migration)偺忈奞偲恄宱嵶朎偺 orientation偺忈奞偑惗偠傞偙偲丄曄堎宆DISC1傕摨條側岠壥傪帵偡偙偲傕柧傜偐偵偟傑偟偨丅 偙傟傜偺寢壥偼丄摑崌幐挷徢偵偍偄偰曬崘偝傟偰偄傞旝嵶側恄宱嵶朎偺攝楍堎忢側偳傪崻嫆偵 巟帩偝傟偰偄傞恄宱敪払忈奞壖愢傪丄偝傜偵巟帩偡傞寢壥偲尵偊傑偡丅
尰嵼丄変乆偼摑崌幐挷徢偺尨場夝柧傪栚巜偟丄DISC1 僲僢僋傾僂僩儅僂僗傗曄堎宆DISC1 僩儔儞 僗僕僃僯僢僋儅僂僗側偳摦暔儌僨儖傪梡偄偨偝傜側傞婡擻夝愅傪偡偡傔偰偄傑偡丅
暥愑丂惛恄壢恄宱壢丂恄扟丂撃 |
|
