| Hiroya Akabori, Hiroshi Yamamoto, Hiroshi Tsuchihashi, Tsuyoshi Mori, Kazunori Fujino, Tomoharu Shimizu, Yoshihiro Endo, Tohru Tani. |
| Transient Receptor Potential Vanilloid 1 antagonist, capsazepine, improves survival in a rat hemorrhagic shock model. |
| Ann Surg.2007 Jun;245(6):964-70. PMID: 17522523 |
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| 弌寣惈僔儑僢僋偵偍偗傞TRPV1漢峈嵻搳梌偺岠壥 |
亂梫巪亃
弌寣惈僔儑僢僋(Hemorrhagic shock; HS)偼椪彴揑偵抳巰棪偑崅偔丄憗婜偺帯椕偑朷傑傟傞昦懺偱偡丅偦偺昦懺惗棟丄摿偵寣埑掅壓偵偍偄偰丄撪場惈傾僫儞僟儅僀僪偑僇儞僫價僲僀僪庴梕懱傪夘偟偰娭梌偡傞偙偲偑嬤擭曬崘偝傟傑偟偨丅撪場惈傾僫儞僟儅僀僪偼TRPV侾(Transient Receptor Potential Vanilloid 1)偺儕僈儞僪偱傕偁傞偙偲偑曬崘偝傟偰偄傑偡丅TRPV侾偼堦師媮怱惈抦妎恄宱枛抂偵懚嵼偟丄條乆側怱寣娗宯嶌梡偵娭梌偟傑偡丅偦偙偱丄TRPV1偑HS偺昦懺儊僇僯僘儉偵娭梌偟偰偄傞偺偱偼側偄偐偲峫偊傑偟偨丅
崱夞変乆偼丄TRPV1漢峈嵻偱偁傞Capsazepine(CPZ)傪丄儔僢僩暯嬒寣埑30mmHg丒90暘娫偺HS儌僨儖偵懳偟偰搳梌偡傞偙偲偵傛傝丄埲壓偺偙偲傪柧傜偐偵偟傑偟偨丅
CPZ偼梕検埶懚惈偵24帪娫惗懚棪偺夵慞岠壥傪擣傔丄懳徠孮偱10亾偺惗懚棪傪5兪mol/kg偺搳梌偱80%偵傑偱夵慞偟傑偟偨丅暯嬒寣埑傪30mmHg偵堐帩偡傞偨傔偵梫偟偨扙寣検偺憹壛丄HS屻偺徃埑嶌梡偲戙幱惈傾僔僪乕僔僗夵慞丄暲傃偵寣塼拞僇僥僐儔儈儞擹搙偺忋徃梷惂摍偺岠壥傪擣傔傑偟偨丅擼姴偵懚嵼偡傞RVLM (rostral ventrolateral medulla) 椞堟偺2廳柶塽壔妛愼怓偵偰丄妶惈壔偝傟偨TH僯儏乕儘儞偺妱崌偑桳堄偵梷惂偝傟傑偟偨丅偙偺偙偲偐傜丄HS偵偍偗傞寣拞僇僥僐儔儈儞暘斿嶌梡偼丄妶惈壔偟偨TRPV1偵傛偭偰墑悜偵懚嵼偡傞僇僥僐儔儈儞娭楢僯儏乕儘儞傪夘偟偰岎姶恄宱宯偵嶌梡偡傞婡彉偑帵嵈偝傟傑偟偨丅CPZ傪搳梌偡傞偙偲偵傛傝丄戙幱惈傾僔僪乕僔僗偲惗懚棪夵慞岠壥傪擣傔偨偙偲傛傝丄CPZ搳梌偑椪彴揑偵崱屻桳梡側帯椕偺堦偮偵側傝摼傞壜擻惈偑帵嵈偝傟傑偟偨丅
TRPV1偑懚嵼偡傞CSSN (Capsaicin sensitive sensory nerve) 偵偼丄拞悤恄宱宯傪夘偟偨媮怱惈嶌梡埲奜偵丄枛徑偱偺恄宱揱払暔幙曻弌偵傛傞墦怱惈嶌梡偑曬崘偝傟偰偄傑偡丅尰嵼丄変乆偼TRPV1偺HS偵偍偗傞恄宱揱払暔幙傪夘偟偨墦怱惈嶌梡偺娭梌偺桳柍偵偮偄偰偝傜側傞昦懺夝愅傪偡偡傔偰偄傑偡丅
暥愑丂奜壢島嵗丂愒杧丂峗栫 |
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