| Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M |
| Adrenergic regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients. |
| Heart Rhythm 2009 Mar 3. [Epub ahead of print] PMID: 19419905 |
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| 帺棩恄宱偵傛傞抶墑惍棳僇儕僂儉揹棳IKr偺挷愡
丗俀宆俻俿墑挿徢岓孮姵幰偵偍偗傞晄惍柆敪徢偲偺娭楢偱 |
亂梫巪亃
攚宨丗KCNH2堚揱巕偺曄堎偼丄IKr揹棳傪尭彮偟偰丄俀宆俻俿墑挿徢岓孮(LQT2)偺昦憸傪敪徢偡傞丅撍慠偺嬃偒傗壒巋寖偵傛傝LQT2姵幰偼怱幒嵶摦傪偍偙偡偑丄偙偺偙偲偼帺棩恄宱傪夘偡傞媫懍側嵜晄惍柆嶌梡偑偁傞偙偲傪帵嵈偟偰偄傞丅
栚揑偲曽朄丗兛1A偍傛傃兝庴梕懱巋寖偑IKr揹棳偵媦傏偡岠壥傪挷傋傞偨傔偵丄変乆偼歁擕椶怱嬝攟梴嵶朎HL-1偺IKr丄wild type偍傛傃LQT2姵幰偱敪尒偝傟偨曄堎KCNH2堚揱巕偵傛傝嵞峔抸偝傟傞Kv11.1僠儍僱儖揹棳傪梡偄偰専摙偟偨丅揹棳偼慡嵶朎宆僷僢僠僋儔儞僾朄傪丄傑偨丄嵶朎撪偺PIP2偺摦懺傪娤嶡偡傞偨傔丄pleckstrin homology偵GFP傪寢崌偝偣偨抈敀偺寀岝傪嫟徟揰宆尠旝嬀偱専弌偟偨丅
寢壥丗HL-1偵兛1A傾僪儗僫儕儞庴梕懱傪敪尰偝偣傞偲丄僼僃僯儗僼儕儞乮兛1A傾僪儗僫儕儞庴梕懱巋寖栻乯偺搳梌偱IKr揹棳偼桳堄偵尭彮偟丄妶惈壔僎乕僩偼扙暘嬌偵僔僼僩偟偰丄扙妶惈壔偑憗傑傞偙偲偑敾柧偟偨丅嫟徟揰宆尠旝嬀偱偺幚尡偱偼丄僼僃僯儗僼儕儞巋寖偵傛傝丄枌偺PI2偑嵶朎撪偵僔僼僩偟偨丅CHO嵶朎傪梡偄偨嵞峔抸幚尡偱傕摨條側寢壥偱偁傝丄LQT2徢椺偱敪尒偝傟偨KCNH2 Y43D, K595E曄堎傕丄wild type偲偺嫟敪尰偱偼丄IKr揹棳検偑尭彮偟偨傕偺偺敪尰偟偰偍傝丄僼僃僯儗僼儕儞巋寖偼丄摨條偵嵞峔抸偝傟偨IKr揹棳傪梷惂偟偨丅
峫埬偲傑偲傔丗LQT2姵幰偱偼丄撍慠偺嬃偒偱QT帪娫偑墑挿偟丄抳巰惈晄惍柆傪桿敪偡傞偙偲偑抦傜傟偰偄傞偑丄彮側偔偲傕偦偺堦晹偵兛1A傾僪儗僫儕儞庴梕懱傪夘偡傞IKr揹棳偺尭彮偑娭梌偟偰偄傞偙偲偑帵嵈偝傟偨丅
暥愑丂撪壢妛島嵗丂杧峕丂柅
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