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| 2012擭1寧18擔
峏怴 |
| 1丏Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S. |
| Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes. |
| Br J Pharmacol 2010 Dec; 161:1734-1750. 丂 PMID: 20718730 |
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| Transient Receptor Potential Canonical 僠儍僱儖傪捠傞Ca2+偺棳擖偑怱嬝偺僇儖僔僂儉僷儔僪僢僋僗彎奞偺敪惗偵娭傢偭偰偄傞丅 |
亂梫巪亃
丂怱憻傪偄偭偨傫Ca2+傪娷傑側偄梟塼偱抁帪娫燇棳偟偨屻偵嵞傃Ca2+傪娷傓梟塼偱燇棳偡傞偲丄媫寖側嵶朎撪Ca2+擹搙偺忋徃偲偦傟偵婲場偡傞嵶朎峉弅丄揹婥揑丒婡夿揑妶摦惈偺徚幐丄儈僩僐儞僪儕傾傊偺Ca2+拁愊丄嵶朎撪僞儞僷僋幙乮儈僆僌儘價儞丄LDH丄CPK乯偺堩扙摍傪摿挜偲偡傞僇儖僔僂儉僷儔僪僢僋僗彎奞偑敪惗偡傞丅堦曽丄嫹怱徢傗媫惈怱嬝峓嵡側偳偺嫊寣惈怱幘姵偱偼丄嫊寣怱嬝傊偺寣棳偑嵞奐偝傟偨偲偒偵丄摨條偺嵶朎撪Ca2+夁晧壸傪摿挜偲偡傞怱嬝嫊寣嵞燇棳彎奞偑敪惗偟丄偦偺尨場偺堦偮偲偟偰僇儖僔僂儉僷儔僪僢僋僗彎奞偺娭梌偑帵嵈偝傟偰偄傞丅
丂杮尋媶榑暥偱偼丄偙偺僇儖僔僂儉僷儔僪僢僋僗彎奞偺敪惗偵娭傢傞暘巕丒嵶朎撪婡峔傪柧傜偐偵偡傞栚揑偱丄嫟徟揰儗乕僓乕尠旝嬀傪梡偄偨嵶朎撪Ca2+僀儊乕僕儞僌朄丄僷僢僠僋儔儞僾朄偍傛傃柶塽嵶朎壔妛朄傪扨棧儅僂僗怱幒嬝嵶朎偵揔梡偟偰丄専摙傪峴偭偨丅偦偺寢壥丄1) 僇儖僔僂儉僷儔僪僢僋僗彎奞偺敪惗偵丄嬤擭怱憻晄惍柆傗怱旍戝偵娭傢傞偙偲偑柧傜偐偵偝傟偰偄傞Transient Receptor Potential Canonical (TRPC) 僠儍僱儖乮偦偺拞偱傕摿偵TRPC1傾僀僜僼僅乕儉乯傪捠傞Ca2+偺棳擖偑娭梌偟偰偄傞偙偲丄2) 偦偺TRPC僠儍僱儖偺妶惈壔偵偼丄Ca2+傪娷傑側偄梟塼偱燇棳拞偵敪惗偡傞嬝彫朎懱撪偺Ca2+娷検偺尭彮偑婑梌偟偰偄傞偙偲丄偑柧傜偐偲側偭偨丅
丂杮尋媶偼丄怱嬝嫊寣嵞燇棳彎奞偺敪惗偵TRPC僠儍僱儖傪夘偡傞Ca2+棳擖偑娭傢偭偰偄傞偲偄偆怴偟偄壜擻惈傪帵嵈偟偨傕偺偱偁傞丅
暥愑丂丂杻悓妛島嵗丂丂彫搱丂垷婓巕
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| 2丏Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S. |
| Sevoflurane protects ventricular myocytes from Ca2+ paradox-mediated Ca2+ overload by blocking the activation of transient receptor potential canonical channels. |
| Anesthesiology 2011 Sep; 115:509-522. |
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| 僙儃僼儖儔儞偼Transient Receptor Potential Canonical 僠儍僱儖偺妶惈壔傪梷惂偡傞偙偲偵傛傝丆僇儖僔僂儉僷儔僪僢僋僗傪夘偡傞Ca2+夁晧壸偐傜怱幒嬝嵶朎傪曐岇偡傞丅 |
亂梫巪亃
丂僙儃僼儖儔儞丄僀僜僼儖儔儞側偳偺媧擖杻悓栻偼丄怱嬝嫊寣嵞燇棳彎奞偺敪惗傪梷惂偡傞偙偲偑抦傜傟偰偍傝丄偙偺嶌梡偼丆廃弍婜偵傒傜傟傞媧擖杻悓栻偺怱嬝曐岇嶌梡偲偟偰拲栚偝傟偰偄傞丅
丂杮尋媶榑暥偱偼丄僙儃僼儖儔儞偺傕偮怱嬝曐岇嶌梡偺暘巕婎斦傪柧傜偐偵偡傞栚揑偱丄怱嬝嫊寣嵞燇棳彎奞偺堦場偱偁傞僇儖僔僂儉僷儔僪僢僋僗彎奞傪幚尡儌僨儖偲偟偰丄偦傟偵懳偡傞僙儃僼儖儔儞偺岠壥傪専摙偟偨丅扨棧儅僂僗怱幒嬝嵶朎傪梡偄偰丄嫟徟揰儗乕僓乕尠旝嬀偵傛傞嵶朎幙撪偲嬝彫朎懱撪偺Ca2+擹搙偺寁應丄偍傛傃僷僢僠僋儔儞僾朄偵傛傞TRPC僠儍僱儖揹棳偺婰榐傪峴偭偨丅偦偺寢壥丄1) 椪彴巊梡擹搙乮俁亾乯偺僙儃僼儖儔儞偼僇儖僔僂儉僷儔僪僢僋僗偺敪惗傪戝偒偔梷惂偡傞偙偲丄2) 僙儃僼儖儔儞偼嬝彫朎懱儕傾僲僕儞庴梕懱偐傜偺Ca2+儕乕僋傪梷惂偟嬝彫朎懱撪Ca2+娷検傪曐帩偡傞偙偲丄3) 僙儃僼儖儔儞偼TRPC僠儍僱儖偵懳偟偰捈愙偵僽儘僢僋嶌梡傪偍傛傏偡偙偲丄偑柧傜偐偲側偭偨丅
丂杮幚尡寢壥偵傛傝丄僙儃僼儖儔儞偼丄1) TRPC僠儍僱儖妶惈壔偺僩儕僈乕偱偁傞嬝彫朎懱撪Ca2+娷検偺尭彮傪梷偊傞偙偲丄偍傛傃2) TRPC僠儍僱儖偵捈愙僽儘僢僋嶌梡傪偍傛傏偡偙偲丄偺俀偮偺儊僇僯僘儉傪夘偟偰僇儖僔僂儉僷儔僪僢僋僗偺敪惗傪梷惂偡傞偲峫偊傜傟偨丅偙偺傛偆偵丄僙儃僼儖儔儞偼TRPC僠儍僱儖偺妶惈壔偵懳偟偰梷惂嶌梡傪傕偪丄偙偺嶌梡偑僙儃僼儖儔儞偺傕偮怱嬝曐岇岠壥偺暘巕婎斦偺堦偮偱偁傞偲峫偊傜傟偨丅
暥愑丂丂杻悓妛島嵗丂丂彫搱丂垷婓巕
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