丂Programmed cell death ligand 1 (PD-L1)偼儅僋儘僼傽乕僕傗庽忬嵶朎側偳偺柶塽嵶朎偵壛偊丄寣娗撪旂嵶朎媦傃忋旂嵶朎側偳偺惓忢嵶朎忋偵敪尰偟丄峈尨偵姶嶌偝傟偨T嵶朎忋偵敪尰偡傞programmed cell death 1 (PD-1)偺儕僈儞僪偲偟偰T嵶朎庴梕懱僔僌僫儖傪梷惂偡傞婡擻傪帩偪丄夁忚側T嵶朎惈柶塽墳摎偺僽儗乕僉偲偟偰廳梫側暘巕偱偁傞丅堦曽丄攛娻傪娷傓條乆側埆惈庮釃偵偍偗傞PD-L1偺堎強惈敪尰偼丄廻庡偵傛傞峈庮釃柶塽墳摎偐傜偺摝旔婡峔偲偟偰摥偔偙偲偑抦傜傟偰偄傞丅

丂僸僩攛娻嵶朎姅僷僱儖偵偍偄偰丄PD-L1梲惈嵶朎偱偼PD-L1堿惈嵶朎偲斾傋偰桳堄偵KRAS傑偨偼EGFR堚揱巕曄堎偺昿搙偑崅偄偙偲偐傜丄偙傟傜偵娭楢偡傞壓棳僔僌僫儖乮RAS-MAPK丄STAT3丄PI3K-AKT乯偺PD-L1敪尰婡峔偵偍偗傞栶妱傪夝愅偟偨丅寢壥丄RAS-MAPK僔僌僫儖偑PD-L1敪尰傪桿摫偡傞庡梫側場巕偺堦偮偱偁傝丄堦曽丄STAT3僔僌僫儖偼堦晹偺攛娻嵶朎偱PD-L1敪尰偵娭傢傞偙偲偑柧傜偐偲側偭偨丅傑偨丄PD-L1梲惈僸僩攛娻嵶朎姅偲堿惈姅偺栐梾揑堚揱巕敪尰夝愅僨乕僞傪梡偄偨Supervised cluster夝愅偍傛傃Gene Set Enrichment Analysis (GSEA)夝愅偱偼丄PD-L1梲惈嵶朎偱MAPK偺壓棳暘巕傪娷傓嵶朎塣摦丒愙拝偵娭傢傞堚揱巕孮偺敪尰傗僔僌僫儖宱楬偺妶惈壔偑擣傔傜傟偨丅

丂MAPK僔僌僫儖傪惂屼偡傞暘巕偺妶惈壔偼丄嵶朎憹怋丒塣摦側偳娻偺埆惈宍幙偵怺偔娭傢傞偑丄堦曽偱娻嵶朎偵偍偗傞PD-L1敪尰傪夘偟偨柶塽摝旔婡峔偵傕娭梌偡傞壜擻惈偑帵嵈偝傟丄怴偨側帯椕愴棯偵婎偯偄偨娻偺暘巕椕朄傪奐敪偡傞忋偱廳梫側抦尒偲峫偊傜傟偨丅